Fluvoxamine, a selective serotonin reuptake inhibitor, and 5-HT2C receptor inactivation induce appetite-suppressing effects in mice via 5-HT1B receptors.

@article{Nonogaki2007FluvoxamineAS,
  title={Fluvoxamine, a selective serotonin reuptake inhibitor, and 5-HT2C receptor inactivation induce appetite-suppressing effects in mice via 5-HT1B receptors.},
  author={Katsunori Nonogaki and Kana Nozue and Yukiko Takahashi and Nobuyuki Yamashita and Shuichi Hiraoka and Hiroaki Kumano and Tomifusa Kuboki and Yohsitomo Oka},
  journal={The international journal of neuropsychopharmacology},
  year={2007},
  volume={10 5},
  pages={675-81}
}
Serotonin (5-hydroxytryptamine; 5-HT) 2C receptors and the downstream melanocortin pathway are suggested to mediate the appetite-suppressing effects of 5-HT drugs such as m-chlorophenylpiperazine (mCPP) and fenfluramine. Here, we report that fluvoxamine (3-30 mg/kg), a selective serotonin reuptake inhibitor (SSRI), in the presence of SB 242084 (1-2 mg/kg), a selective 5-HT2C receptor antagonist, exerts appetite-suppressing effects while fluvoxamine or SB 242084 alone has no effect. The appetite… CONTINUE READING
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