Fluvastatin reduces proliferation and increases apoptosis in women with high grade breast cancer

@article{Garwood2009FluvastatinRP,
  title={Fluvastatin reduces proliferation and increases apoptosis in women with high grade breast cancer},
  author={Elisabeth R. Garwood and A. V. Satish Siva Kumar and Frederick L. Baehner and D Helen Moore and Alfred Au and Nola Hylton and Chris I. Flowers and Judy Garber and B Lesnikoski and E. Shelley Hwang and Olofunmilao Olopade and Elisa Rush Port and M J Campbell and Laura Esserman},
  journal={Breast Cancer Research and Treatment},
  year={2009},
  volume={119},
  pages={137-144}
}
The purpose of this study is to determine the biologic impact of short-term lipophilic statin exposure on in situ and invasive breast cancer through paired tissue, blood and imaging-based biomarkers. A perioperative window trial of fluvastatin was conducted in women with a diagnosis of DCIS or stage 1 breast cancer. Patients were randomized to high dose (80 mg/day) or low dose (20 mg/day) fluvastatin for 3–6 weeks before surgery. Tissue (diagnostic core biopsy/final surgical specimen), blood… CONTINUE READING
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James Ford

  • J Ford A phase II trial of lovastatin for modificati cytology, risk-associated biomarkers in women at high inherited risk of brea Investigator
  • http:// clinicaltrials.gov/ct2/show/NCT00285857…
  • 2010
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