Fluvastatin reduces oxidative damage in human vascular endothelial cells by upregulating Bcl-2.

@article{Xu2008FluvastatinRO,
  title={Fluvastatin reduces oxidative damage in human vascular endothelial cells by upregulating Bcl-2.},
  author={Shang-Zhong Xu and Wenyu Zhong and Nancy M Watson and Eric Dickerson and Jo Dugstad Wake and Steve W Lindow and Chris J. P. Newton and Stephen L Atkin},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2008},
  volume={6 4},
  pages={692-700}
}
BACKGROUND 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) have been widely used in clinical practise and their efficacy in reducing cardiovascular risk has been well described. OBJECTIVES To investigate the effect of low doses of fluvastatin (nanomolar) on H(2)O(2)-induced cell damage and the underlying mechanism. METHODS AND RESULTS Primary cultures of human umbilical vein endothelial cells were used, and the effects of fluvastatin on H(2)O(2)-induced apoptosis… CONTINUE READING

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