Fluticasone Propionate Protects against Ozone-Induced Airway Inflammation and Modified Immune Cell Activation Markers in Healthy Volunteers

@inproceedings{Alexis2008FluticasonePP,
  title={Fluticasone Propionate Protects against Ozone-Induced Airway Inflammation and Modified Immune Cell Activation Markers in Healthy Volunteers},
  author={Neil E. Alexis and John C. Lay and Angela Haczku and Henry Gong and William S. Linn and Milan Hazucha and Brad Harris and Ruth Tal-Singer and David B. Peden},
  booktitle={Environmental health perspectives},
  year={2008}
}
BACKGROUND Ozone exposure induces airway neutrophilia and modifies innate immune monocytic cell-surface phenotypes in healthy individuals. High-dose inhaled corticosteroids can reduce O(3)-induced airway inflammation, but their effect on innate immune activation is unknown. OBJECTIVES We used a human O(3) inhalation challenge model to examine the effectiveness of clinically relevant doses of inhaled corticosteroids on airway inflammation and markers of innate immune activation in healthy… CONTINUE READING

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