Flutamide in the treatment of hirsutism

@article{Motta1991FlutamideIT,
  title={Flutamide in the treatment of hirsutism},
  author={Tiziano Motta and G C Maggi and Maria Teresa Perra and E Azzolari and S Casazza and Alberto D'Alberton},
  journal={International Journal of Gynecology \& Obstetrics},
  year={1991},
  volume={36}
}
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34 Citations
Background Citations
2
Results Citations
1

34 Citations

The Use of Antiandrogen of Hirsutism Flutamide in the Treatment
TLDR
Clinical examinations revealed that after six months of the therapy the dose of flutamide had caused a significant alleviation of hirsutism and this continued during the following months.
The use of antiandrogen flutamide in the treatment of hirsutism.
TLDR
Clinical examinations revealed that after six months of the therapy the dose of flutamide had caused a significant alleviation of hirsutism and this continued during the following months.
Treatment of hirsutism by finasteride and flutamide in women with polycystic ovary syndrome.
TLDR
Finasteride and flutamide are effective in the treatment of hirsutism in patients with polycystic ovary syndrome and both antiandrogens significantly reduced the Ferriman-Gallwey score and hair diameter.
The efficacy of 250 mg/day flutamide in the treatment of patients with hirsutism.
Comparison of finasteride and flutamide in the treatment of idiopathic hirsutism.
Antiandrogen and hormonal treatment of acne.
  • J. C. Shaw
  • Medicine, Biology
    Dermatologic clinics
  • 1996
Treatment of hirsutism: comparisons between different antiandrogens with central and peripheral effects.
UPDATE ON IDIOPATHIC HIRSUTISM: DIAGNOSIS AND TREATMENT
  • C. Erem
  • Medicine, Biology
    Acta clinica Belgica
  • 2013
TLDR
Combination treatment of IH, including androgen suppression, peripheral androgen blockade and cosmetic methods is most effective.
Flutamide in the treatment of hirsutism: long-term clinical effects, endocrine changes, and androgen receptor behavior.
Very low dose of flutamide in the treatment of hyperandrogenism
TLDR
Very low dose of flutamide was successful and safe and in the treatment of hyperandrogenism in adolescence and an almost recovery of acne (98% of patients) with better results of those obtained in control group.
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References

SHOWING 1-10 OF 11 REFERENCES
Flutamide. Mechanism of action of a new nonsteroidal antiandrogen.
TLDR
Flutamide is a new nonsteroidal antiandrogen useful in the treatment of prostatic carcinoma and is capable of inhibiting prostatic nuclear uptake of androgen.
Clinical assessment of body hair growth in women.
TLDR
A method was developed for the semiquantitative assessment of body hair growth, and suitable for use in the study of clinical problems associated with hirsuties in women, and an “hormonal” score obtained by adding the gradings obtained from 9 of the 11 sites is being employed in clinical studies.
Effect of flutamide on estradiol metabolism.
TLDR
This study demonstrates that flutamide produces multiple functional, reversible, cirrhosis-like disturbances of steroid metabolism, which are universal in the patients studied regardless of whether they had clinical responses toFlutamide, and doubts that the steroid metabolic changes play a role in the therapeutic effect of the drug.
Experience with flutamide in patients with advanced prostatic cancer without prior endocrine therapy
TLDR
Flutamide appears to be a safe antiandrogen, usually effective in the management of patients with advanced prostatic cancer who have had no prior endocrine therapy.
A biological profile of a nonsteroidal antiandrogen, SCH 13521 (4'-nitro-3'trifluoromethylisobutyranilide).
TLDR
A comparative study in castrated rats revealed that Sch 13521 was equipotent to cyproterone acetate (CPA) as an antiandrogen, but unlike CPA, it did not effect parturition time.
Comparison of the antiandrogenic/androgenic activities of flutamide, cyproterone acetate and megestrol acetate
Effect of tlutamide on estradiol metabolism
  • J Clin Endocrinol Metab
  • 1979
Gambrell KD ( eds ) : The Cause and Management of Hirsutism . Parthenon . Carnforth , UK , 1987 . prior endocrine therapy
    Experience with fhnamide in patients with advanced prostatic cancer without
      A biological prima CBnier ostetried;ineenlngicsl profile of a nonsteroidal antiandrogen. SCH 13521 L. MuqJagaBi Via Cnnnnend~ 12 (4'~nitro-3'-trifluoromethylisobutyranilide)
      • Endocrinology
      • 1972
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