Flutamide fails to reduce resuscitation requirements in a porcine ischemia-reperfusion model.


BACKGROUND Hemorrhagic shock and subsequent resuscitation can lead to ischemia-reperfusion injury, followed by multiorgan failure and death. Flutamide, a vasoactive nonsteroidal antiandrogen compound, is thought to improve tissue and organ perfusion. We tested whether administration of flutamide-cyclodextrin (FLU-CYD) alters physiologic parameters or… (More)
DOI: 10.1016/j.jss.2013.04.083


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