Flutamide: a novel agent for restoring the depressed cell-mediated immunity following soft-tissue trauma and hemorrhagic shock.

@article{Wichmann1997FlutamideAN,
  title={Flutamide: a novel agent for restoring the depressed cell-mediated immunity following soft-tissue trauma and hemorrhagic shock.},
  author={Matthias W. Wichmann and Martin Kurt Angele and Alfred Ayala and William G. Cioffi and Irshad H. Chaudry},
  journal={Shock},
  year={1997},
  volume={8 4},
  pages={242-8}
}
Recent studies indicate beneficial effects of androgen depletion in male mice, before trauma-hemorrhage on cell-mediated immunity following soft-tissue trauma and hemorrhagic shock. Nonetheless, it remains unknown whether androgen receptor blockade following the insult has any salutary effects. To study this, male C3H/HeN mice were either sham-operated or subjected to soft-tissue trauma (i.e., 2.5 cm midline laparotomy) followed by hemorrhagic shock (blood pressure 35 +/- 5 mmHg for 90 min) and… CONTINUE READING

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