Flutamide: An Antiandrogen for Advanced Prostate Cancer

@article{Goldspiel1990FlutamideAA,
  title={Flutamide: An Antiandrogen for Advanced Prostate Cancer},
  author={Barry R. Goldspiel and David R. Kohler},
  journal={Annals of Pharmacotherapy},
  year={1990},
  volume={24},
  pages={616 - 623}
}
Flutamide is a nonsteroidal pure antiandrogen that acts by inhibiting the uptake and/or binding of dihydrotestosterone to the target cell receptor, thus interfering with androgen action. Flutamide is well absorbed orally and extensively metabolized; its active metabolite, 2-hydroxyflutamide, is formed rapidly and excreted almost entirely by the kidneys. Clinical studies in prostate cancer patients have demonstrated efficacy with flutamide monotherapy in patients who had received no prior… 
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49 Citations

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The importance of androgen signaling in prostate cancer biology and advances made over the years to effectively target this signaling pathway are described and the potential of this knowledge for translation into future therapies for prostate cancer is discussed.
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An overview of the mutation based resistance of the current clinically used antiandrogens and the rational drug design to overcome the resistance is given, which provides a promising strategy for the development of the new generation of antiandrogen targeting HBP.
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A screening paradigm to identify compounds with novel mechanisms of action to prevent or delay resistance to castration resistant prostate cancer is designed, which would prevent the transcription of both AR-FL and AR-V7 thereby providing a dual approach to preventing CRPC progression.
Modulation of Ovarian Structure and Abdominal Obesity in Curcumin- and Flutamide-treated Aging FSH-R Haploinsufficient Mice
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Changes in ovarian histology and oocyte components as well as adipose tissue indicate the potential for reversing ovarian decline and metabolism because of mild hyperandrogenemia that occurs with aging in follicle-stimulating hormone receptor haploinsufficienct mice.
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