Fluselenamyl: A Novel Benzoselenazole Derivative for PET Detection of Amyloid Plaques (Aβ) in Alzheimer’s Disease

@inproceedings{Sundaram2016FluselenamylAN,
  title={Fluselenamyl: A Novel Benzoselenazole Derivative for PET Detection of Amyloid Plaques (Aβ) in Alzheimer’s Disease},
  author={G. S. M. Sundaram and Dhruva D Dhavale and Julie L. Prior and Ping Wang Yan and John R Cirrito and Nigam P Rath and Richard Laforest and Nigel J. Cairns and Jin-Moo Lee and Paul T. Kotzbauer and Vijay Lakshami Sharma},
  booktitle={Scientific reports},
  year={2016}
}
Fluselenamyl (5), a novel planar benzoselenazole shows traits desirable of enabling noninvasive imaging of Aβ pathophysiology in vivo; labeling of both diffuse (an earlier manifestation of neuritic plaques) and fibrillar plaques in Alzheimer's disease (AD) brain sections, and remarkable specificity for mapping Aβ compared with biomarker proteins of other neurodegenerative diseases. Employing AD homogenates, [18F]-9, a PET tracer demonstrates superior (2-10 fold higher) binding affinity than… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 15 times over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.

References

Publications referenced by this paper.
Showing 1-10 of 71 references

Structure-Activity Relationship Study of Heterocyclic Phenylethenyl and Pyridinylethenyl Derivatives as TauImaging Agents That Selectively Detect Neurofibrillary Tangles in Alzheimer’s Disease Brains

  • K Matsumura
  • J. Med. Chem
  • 2015

Synthesis, characterization, and preclinical validation of a PET radiopharmaceutical for interrogating Abeta (beta-amyloid) plaques in Alzheimer’s disease

  • Sundaram, S G.
  • EJNMMI research
  • 2015

Characterization of a brain permeant fluorescent molecule and visualization of Aβ parenchymal plaques, using real-time multiphoton imaging in transgenic mice

  • G Sundaram
  • Org. Lett. 16,
  • 2014

Design and synthesis of a novel PET probe for early detection of Alzheimer’s disease

  • G. Sundaram, N. Cairns, Lee, J.-M, V. Sharma
  • J. Nucl. Med. 55,
  • 2014

One pot preparation of 2-(alkyl)arylbenzoselenazoles from the coressponding N-(acetyl)benzoyl-2-iodoanilines via a microwave assisted methodology

  • S. Redon, Y. Kabri, M. Crozet, P. Vanelle
  • Tet Lett 55,
  • 2014

Similar Papers

Loading similar papers…