Flurofamide: a potent inhibitor of bacterial urease with potential clinical utility in the treatment of infection induced urinary stones.

@article{Millner1982FlurofamideAP,
  title={Flurofamide: a potent inhibitor of bacterial urease with potential clinical utility in the treatment of infection induced urinary stones.},
  author={O. Elmo Millner and J A Andersen and Matthew Appler and C. Benjam{\'i}n and John G. Edwards and D T Humphrey and E M Shearer},
  journal={The Journal of urology},
  year={1982},
  volume={127 2},
  pages={
          346-50
        }
}
AbstractA novel compound, N-[diaminophosphinyl]-4-fluorobenzamide (given the USAN name flurofamide), has been found to be a potent inhibitor of bacterial urease. The compound, coded EU-4534, is approximately 1000 times more potent than acetohydroxamic acid as an inhibitor of the urease in intact P. mirabilis cells. Flurofamide is excreted in the urine of rats and dogs following oral administration and is effective in retarding stone formation in the urinary tract of rats infected with P… 
Effect of Potent Urease Inhibitor, Fluorofamide, on Helicobacter sp. in Vivo and in Vitro
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Flurofamide (N-[diaminophosphinyl]-4-fluorobenzamide), a urease inhibitor, was a potent inhibitor of the growth of Ureaplasma urealyticum. As little as 10 microM flurofamide (2 micrograms/ml)
Ureases as a target for the treatment of gastric and urinary infections
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This is a review of the role of ureases in H pylori and Proteus species infections, focussing on the biochemical and clinical aspects of the most promising and/or potent urease inhibitors for the treatment of gastric and urinary tract infections.
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The ecology and pathogenicity of urease-producing bacteria in the urinary tract.
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Results suggest that urease inhibitors may be useful for treating urinary tract infections caused by Staph.
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The Urease of C. pylori appears to be biochemically unique from the enzymes of other common urease-producing species.
Stone formation by Ureaplasma urealyticum in human urine and its prevention by urease inhibitors
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It seems that stone formation by U. urealyticum is prevented with these compounds, that prevention being directly attributable to the inhibition of urease activity, which causes the death of the cells.
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