Fluridil, a Rationally Designed Topical Agent for Androgenetic Alopecia: First Clinical Experience

  title={Fluridil, a Rationally Designed Topical Agent for Androgenetic Alopecia: First Clinical Experience},
  author={M. Sov{\'a}k and A. Seligson and R. Ku{\vc}erov{\'a} and Marie Bienova and M. Hajd{\'u}ch and M. Bu{\vc}ek},
  journal={Dermatologic Surgery},
  • M. Sovák, A. Seligson, +3 authors M. Buček
  • Published 2002
  • Medicine
  • Dermatologic Surgery
  • BACKGROUND Fluridil, a novel topical antiandrogen, suppresses the human androgen receptor. While highly hydrophobic and hydrolytically degradable, it is systemically nonresorbable. In animals, fluridil demonstrated high local and general tolerance. OBJECTIVE To evaluate the safety and efficacy of a topical anti- androgen, fluridil, in male androgenetic alopecia. METHODS In 20 men, for 21 days, occlusive forearm patches with 2, 4, and 6% fluridil, isopropanol, and/or vaseline were applied. In 43… CONTINUE READING
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