Flupirtine shows functional NMDA receptor antagonism by enhancing Mg2+ block via activation of voltage independent potassium channels

@article{Kornhuber1999FlupirtineSF,
  title={Flupirtine shows functional NMDA receptor antagonism by enhancing Mg2+ block via activation of voltage independent potassium channels},
  author={Johannes Kornhuber and Stefan Bleich and Jens Wiltfang and Manuel Maler and Chris G. Parsons},
  journal={Journal of Neural Transmission},
  year={1999},
  volume={106},
  pages={857-867}
}
Summary. The spectrum of action of flupirtine includes analgesia, muscle relaxation and neuroprotection. N-methyl-D-aspartate (NMDA) receptor antagonism has been discussed as a possible mechanism of action of this compound with little direct evidence. The objective of the present study was to develop a plausible model to explain flupirtine's spectrum of action. A four-stage strategy was selected for this purpose: Firstly, the serum concentration of flupirtine under therapeutic conditions was… 

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