Flupirtine in Pain Management

  title={Flupirtine in Pain Management},
  author={J. Devulder},
  journal={CNS Drugs},
  • J. Devulder
  • Published 2010
  • Medicine
  • CNS Drugs
  • Flupirtine is a centrally acting, non-opioid analgesic that is available in a number of European countries for the treatment of a variety of pain states. The therapeutic benefits seen with flupirtine relate to its unique pharmacological properties. Flupirtine displays indirect NDMA receptor antagonism via activation of potassium channels and is the first representative of a pharmacological class denoted the ‘selective neuronal potassium channel openers’. The generation of the M-current is… CONTINUE READING
    Flupirtine: A Narrative Review of Its Role in Acute and Chronic Pain Management
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    Pharmacokinetics and disposition of flupirtine in the horse.
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    • Highly Influenced
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    Role of Muscle Relaxants in the Treatment of Pain
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    Publications referenced by this paper.
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    Flupirtine: A Review of Its Neuroprotective and Behavioral Properties
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    Combination therapy with flupirtine and opioid: studies in rat pain models.
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    Dose-related analgesic effects of flupirtine.
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    [Neuronal potassium channel opening with flupirtine].
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    Clinical experience with flupirtine in the U.S.
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