Flupirtine Determination in Human Blood Plasma by HPLC with Mass-Spectrometric Detection and its Application to Pharmacokinetic Studies

@article{Krasnykh2018FlupirtineDI,
  title={Flupirtine Determination in Human Blood Plasma by HPLC with Mass-Spectrometric Detection and its Application to Pharmacokinetic Studies},
  author={Liudmila M Krasnykh and Tatyana A Rodina and E. S. Mel’nikov and G. F. Vasilenko and Valery V. Smirnov and Alexey V Sokolov and V. V. Arkhipov},
  journal={Pharmaceutical Chemistry Journal},
  year={2018},
  volume={51},
  pages={1123-1128}
}
A validated method for quantitative determination of flupirtine in human blood plasma using liquid chromatography combined with tandem mass spectrometry (HPLC-MS/MS) was proposed. Biological samples were prepared by precipitating proteins using MeOH. The chromatographic separation used a Zorbax Eclipse Plus C18 column with gradient elution. A Shimadzu 8040… CONTINUE READING