Flupirtine, a re-discovered drug, revisited

@article{Szelenyi2013FlupirtineAR,
  title={Flupirtine, a re-discovered drug, revisited},
  author={Istvan Prof Szelenyi},
  journal={Inflammation Research},
  year={2013},
  volume={62},
  pages={251-258}
}
  • I. Szelenyi
  • Published 16 January 2013
  • Biology, Medicine
  • Inflammation Research
Flupirtine was developed long before KV7 (KCNQ) channels were known. However, it was clear from the beginning that flupirtine is neither an opioid nor a nonsteroidal anti-inflammatory analgesic. Its unique muscle relaxing activity was discovered by serendipity. In the meantime, broad and intensive research has resulted in a partial clarification of its mode of action. Flupirtine is the first therapeutically used KV7 channel activator with additional GABAAergic mechanisms and thus the first… 

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