Flupirtine, a re-discovered drug, revisited

  title={Flupirtine, a re-discovered drug, revisited},
  author={I. Szel{\'e}nyi},
  journal={Inflammation Research},
  • I. Szelényi
  • Published 2013
  • Medicine, Chemistry
  • Inflammation Research
  • Flupirtine was developed long before KV7 (KCNQ) channels were known. However, it was clear from the beginning that flupirtine is neither an opioid nor a nonsteroidal anti-inflammatory analgesic. Its unique muscle relaxing activity was discovered by serendipity. In the meantime, broad and intensive research has resulted in a partial clarification of its mode of action. Flupirtine is the first therapeutically used KV7 channel activator with additional GABAAergic mechanisms and thus the first… CONTINUE READING

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