Fluoxetine reverts chronic restraint stress-induced depression-like behaviour and increases neuropeptide Y and galanin expression in mice.

@article{Christiansen2011FluoxetineRC,
  title={Fluoxetine reverts chronic restraint stress-induced depression-like behaviour and increases neuropeptide Y and galanin expression in mice.},
  author={S. Christiansen and Mikkel Vestergaard Olesen and Gitta W{\"o}rtwein and David Paul Drucker Woldbye},
  journal={Behavioural brain research},
  year={2011},
  volume={216 2},
  pages={585-91}
}
Stressful life events and chronic stress are implicated in the development of depressive disorder in humans. Neuropeptide Y (NPY) and galanin have been shown to modulate the stress response, and exert antidepressant-like effects in rodents. To further investigate these neuropeptides in depression-like behaviour, NPY and galanin gene expression was studied in brains of mice subjected to chronic restraint stress (CRS) and concomitant treatment with the antidepressant fluoxetine (FLX). CRS caused… CONTINUE READING

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