Fluoxetine protects hippocampal plasticity during conditioned fear stress and prevents fear learning potentiation

@article{Spennato2007FluoxetinePH,
  title={Fluoxetine protects hippocampal plasticity during conditioned fear stress and prevents fear learning potentiation},
  author={Guillaume Spennato and Carine Zerbib and Cesare G Mondadori and Rene Henriquez Garcia},
  journal={Psychopharmacology},
  year={2007},
  volume={196},
  pages={583-589}
}
Contextual fear conditioning can produce both changes in hippocampal synaptic efficacy and potentiation of subsequent fear learning. In this study, we tested whether fluoxetine reverses these effects. In the first experiment, we examined alterations of baseline synaptic efficacy and induction of synaptic plasticity in the CA3 region of the hippocampus during re-exposure of rats, treated with fluoxetine (7 mg/kg) or vehicle, in a context where they previously received 15 eyelid shocks or no… CONTINUE READING
11 Citations
20 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 20 references

Similar Papers

Loading similar papers…