Fluoxetine potentiation of omega-3 fatty acid antidepressant effect: evaluating pharmacokinetic and brain fatty acid-related aspects in rodents.

@article{Laino2014FluoxetinePO,
  title={Fluoxetine potentiation of omega-3 fatty acid antidepressant effect: evaluating pharmacokinetic and brain fatty acid-related aspects in rodents.},
  author={C. Laino and P. Garc{\'i}a and Mar{\'i}a Fernanda Podest{\'a} and C. H{\"o}cht and N. Slobodianik and A. Reines},
  journal={Journal of pharmaceutical sciences},
  year={2014},
  volume={103 10},
  pages={
          3316-25
        }
}
  • C. Laino, P. García, +3 authors A. Reines
  • Published 2014
  • Chemistry, Medicine
  • Journal of pharmaceutical sciences
  • We previously reported that combined fluoxetine administration at antidepressant doses renders additive antidepressant effects, whereas non-antidepressant doses potentiate the omega-3 fatty acid antidepressant effect. In the present study, we aimed to evaluate putative pharmacokinetic and brain omega-3 fatty acid-related aspects for fluoxetine potentiation of omega-3 fatty acid antidepressant effect in rats. Coadministration of omega-3 fatty acids with a non-antidepressant dose of fluoxetine (1… CONTINUE READING
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