Fluoxetine-mediated 5-HT2B receptor stimulation in astrocytes causes EGF receptor transactivation and ERK phosphorylation

Abstract

Fluoxetine has relatively high affinity for Gq/11 protein-coupled 5-HT2 receptors. Part of these receptors in brain are on astrocytes, where fluoxetine causes an increase in free cytosolic calcium concentration ([Ca2+]i) and phosphorylation of extracellular regulated kinase 1 and 2 (ERK1/2). The objectives of the study are to identify subtype of the 5-HT2… (More)
DOI: 10.1007/s00213-008-1306-5

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