Fluoxetine kinetics and protein binding in normal and impaired renal function.

  title={Fluoxetine kinetics and protein binding in normal and impaired renal function.},
  author={George R. Aronoff and Richard F. Bergstrom and Scott T. Pottratz and Richard Schmalensee Sloan and Robert L. Wolen and L Lemberger},
  journal={Clinical pharmacology and therapeutics},
  volume={36 1},
The effect of decreased renal function on the disposition and elimination of the nontricyclic antidepressant fluoxetine was examined in 25 adult male subjects after a single 40-mg oral dose. Blood samples for the measurement of fluoxetine and its active metabolite norfluoxetine were drawn 13 times in the first 48 hr after dosing and thrice weekly thereafter for 4 wk. All urine was collected in daily aliquots for 4 wk and was assayed for fluoxetine and norfluoxetine concentrations. The extent of… CONTINUE READING

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