Fluoxetine inhibits inflammatory response and bone loss in a rat model of ligature-induced periodontitis.

@article{BrancodeAlmeida2012FluoxetineII,
  title={Fluoxetine inhibits inflammatory response and bone loss in a rat model of ligature-induced periodontitis.},
  author={Luciana Salles Branco-de-Almeida and Gilson C{\'e}sar Nobre Franco and Myrella Lessio Castro and Juliana Guimar{\~a}es Dos Santos and Ana Lia Anbinder and Sheila Cavalca Cortelli and Mikihito Kajiya and Toshihisa Kawai and Pedro Luiz Rosalen},
  journal={Journal of periodontology},
  year={2012},
  volume={83 5},
  pages={664-71}
}
BACKGROUND Fluoxetine, a selective serotonin reuptake inhibitor, has been found recently to possess anti-inflammatory properties. The present study investigates the effects of fluoxetine on inflammatory tissue destruction in a rat model of ligature-induced periodontal disease. METHODS Thirty male Wistar rats were randomly assigned into three groups (n = 10 animals per group): 1) control rats (without ligature); 2) rats with ligature + placebo (saline; oral gavage); and 3) rats with ligature… CONTINUE READING
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