Fluoxetine inhibits ATP-induced [Ca(2+)](i) increase in PC12 cells by inhibiting both extracellular Ca(2+) influx and Ca(2+) release from intracellular stores.

@article{Kim2005FluoxetineIA,
  title={Fluoxetine inhibits ATP-induced [Ca(2+)](i) increase in PC12 cells by inhibiting both extracellular Ca(2+) influx and Ca(2+) release from intracellular stores.},
  author={Hee Jung Kim and Jin Sung Choi and Yeo-Min Lee and Eun Young Shim and Sun Hwa Hong and Myung-jun Kim and Do Sik Min and D. H. Rhie and Myung-suk Kim and Y Y Jo and Sang June Hahn and Shin Hee Yoon},
  journal={Neuropharmacology},
  year={2005},
  volume={49 2},
  pages={265-74}
}
Fluoxetine, a widely used antidepressant, has additional effects, including the blocking of voltage-gated ion channels. We examined whether fluoxetine affects ATP-induced calcium signaling in PC12 cells using fura-2-based digital calcium imaging, an assay for [3H]-inositol phosphates (IPs) and whole-cell patch clamping. Treatment with ATP (100 microM) for 2… CONTINUE READING