Fluoxetine-induced suicidality, serotonin, and seasonality.

  title={Fluoxetine-induced suicidality, serotonin, and seasonality.},
  author={Timothy D. Brewerton},
  journal={Biological psychiatry},
  volume={30 2},
In spite of the complexities involved in suicide, fluoxetine has been prematurely and simplistically blamed for inducing this phenomenon. A variety of variables must be factored into such an interpretation. Nevertheless, given the complicated psychobiological circumstances involved, acute and rapid changes in serotonin (5-HT) function appear to be important to the understanding of changes in suicidal behavior. Such a mechanism may also explain the robust seasonal peak of suicides in spring.