Fluoxetine-induced changes in body weight and 5-HT1A receptor-mediated hormone secretion in rats on a tryptophan-deficient diet.

@article{Dsouza2004FluoxetineinducedCI,
  title={Fluoxetine-induced changes in body weight and 5-HT1A receptor-mediated hormone secretion in rats on a tryptophan-deficient diet.},
  author={D N D'souza and Yutong Zhang and Francisca Abad Garc{\'i}a and Giuseppe Battaglia and Louis D van de Kar},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2004},
  volume={286 2},
  pages={
          R390-7
        }
}
Tryptophan depleting protocols are commonly used to study the role of serotonin in mood disorders. The present study examined the impact of a tryptophan-deficient diet and fluoxetine on the serotonergic regulation of neuroendocrine function and body weight. We hypothesized that the regulation of postsynaptic 5-HT1A receptors is dependent on the levels of 5-HT in the synapse. Rats on a control or a tryptophan-deficient diet received daily injections of saline or fluoxetine (5 or 10 mg.kg-1.day-1… CONTINUE READING

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