Fluoxetine improves the memory deficits caused by the chemotherapy agent 5-fluorouracil.

@article{ElBeltagy2010FluoxetineIT,
  title={Fluoxetine improves the memory deficits caused by the chemotherapy agent 5-fluorouracil.},
  author={Maha ElBeltagy and Sarah Mustafa and Jariya Umka and Laura Lyons and Ahmed Salman and Gloria Tu Chur-yoe and Nikita Bhalla and Geoffrey Bennett and Peter M. Wigmore},
  journal={Behavioural brain research},
  year={2010},
  volume={208 1},
  pages={112-7}
}
Cancer patients who have been treated with systemic adjuvant chemotherapy have described experiencing deteriorations in cognition. A widely used chemotherapeutic agent, 5-fluorouracil (5-FU), readily crosses the blood-brain barrier and so could have a direct effect on brain function. In particular this anti mitotic drug could reduce cell proliferation in the neurogenic regions of the adult brain. In contrast reports indicate that hippocampal dependent neurogenesis and cognition are enhanced by… CONTINUE READING

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