Fluoxetine disrupts motivation and GABAergic signaling in adolescent female hamsters.

@article{Shannonhouse2016FluoxetineDM,
  title={Fluoxetine disrupts motivation and GABAergic signaling in adolescent female hamsters.},
  author={John L Shannonhouse and Dustin W Dubois and Annette S Fincher and Alejandra M Vela and Morgan M Henry and Paul J. Wellman and Gerald D. Frye and C. L. S. Morgan},
  journal={Progress in neuro-psychopharmacology & biological psychiatry},
  year={2016},
  volume={69},
  pages={19-30}
}
Initial antidepressant treatment can paradoxically worsen symptoms in depressed adolescents by undetermined mechanisms. Interestingly, antidepressants modulate GABAA receptors, which mediate paradoxical effects of other therapeutic drugs, particularly in females. Although the neuroanatomic site of action for this paradox is unknown, elevated GABAA receptor… CONTINUE READING