Fluoxetine differentially alters alcohol intake and other consummatory behaviors in problem drinkers

@article{Naranjo1990FluoxetineDA,
  title={Fluoxetine differentially alters alcohol intake and other consummatory behaviors in problem drinkers},
  author={Claudio A. Naranjo and Karen E Kadlec and Pablo Sanhueza and D Woodley-Remus and Edward Sellers},
  journal={Clinical Pharmacology \& Therapeutics},
  year={1990},
  volume={47}
}
The effects of fluoxetine, a relatively selective long‐acting serotonin uptake inhibitor, on the consumption of alcoholic and nonalcoholic drinks, cigarette smoking, and body weight were assessed in 29 men who were early stage problem drinkers. After a 2‐week baseline, subjects were randomly assigned to receive 40 mg/day fluoxetine (n = 8), 60 mg/day fluoxetine (n = 11), or placebo (n = 10) for 4 weeks. Fluoxetine 60 mg/day decreased mean daily alcoholic drinks from (X̄ ± SEM) 8.3 ± 0.7 during… Expand
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References

SHOWING 1-10 OF 37 REFERENCES
Differential effects of viqualine on alcohol intake and other consummatory behaviors
TLDR
It is indicated that viqualine both attenuates ethanol intake and reduces body weight in human beings. Expand
Do serotonin uptake inhibitors decrease smoking? Observations in a group of heavy drinkers.
TLDR
Zimelidine and citalopram effects on ethanol intake and smoking behavior were evaluated to exclude with 99.99% confidence the possibility that these drugs decrease smoking behavior by 50%. Expand
Zimelidine‐induced variations in alcohol intake by nondepressed heavy drinkers
TLDR
The data suggest that zimelidine modifies alcohol intake by a different mechanism than previously tested drugs, possibly by modulating the central neural mechanism that controls drinking of alcohol. Expand
The serotonin uptake inhibitor citalopram attenuates ethanol intake
TLDR
Citalopram, a selective serotonin uptake inhibitor, decreased the number of drinks consumed and increased the numbers of abstinent days in male nondepressed early‐stage problem drinkers and is probably through modulation of the neurobiologic mechanisms regulating ethanol intake. Expand
Use of a serotonin re-uptake inhibitor, fluoxetine, in the treatment of obesity.
TLDR
Fluoxetine appears to be safe and effective in inducing weight loss over periods of up to 8 weeks and the weight loss was correlated with the degree of obesity in the fluoxettine-treated patients. Expand
Serotonin uptake blockers and the treatment of alcoholism.
  • D. Gorelick
  • Medicine
  • Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism
  • 1989
TLDR
In four human, double-blind, placebo-controlled studies, citalopram, fluoxetine, and zimelidine significantly reduced alcohol intake 10-26% in social drinkers, early problem drinkers, and chronic alcoholics. Expand
Ethanol interactions with serotonin uptake selective and non‐selective antidepressants: Fluoxetine and amitriptyline
TLDR
Ethanol dose does not interact importantly with clinically relevant doses of fluoxetine or low doses of amitriptyline administered chronically, and the deleterious effects of ethanol on memory, manual tracking, body sway, intoxication and sedation were not modified. Expand
Attenuation of alcohol intake by a serotonin uptake inhibitor: Evidence for mediation through the renin-angiotensin system
TLDR
Findings indicate that the fluoxetine-induced reduction in alcohol intake may, in part, be mediated through the renin-angiotensin system. Expand
Fluoxetine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness.
TLDR
Fluoxetine has overall therapeutic efficacy comparable with imipramine, amitriptyline and doxepin in patients with unipolar depression treated for 5 to 6 weeks, although it may be less effective than tricyclic antidepressants in relieving sleep disorders in depressed patients. Expand
A review of multicenter controlled studies of fluoxetine vs. imipramine and placebo in outpatients with major depressive disorder.
TLDR
Fluoxetine had significantly less associated anticholinergic effects, dizziness, drowsiness, somatosensory disturbance, and excessive sweating than imipramine, and although nausea occurred more frequently in fluoxettine patients, it was generally mild and well tolerated. Expand
...
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