Fluoxetine coupled with zinc in a chronic mild stress model of depression: Providing a reservoir for optimum zinc signaling and neuronal remodeling.

@article{Omar2017FluoxetineCW,
  title={Fluoxetine coupled with zinc in a chronic mild stress model of depression: Providing a reservoir for optimum zinc signaling and neuronal remodeling.},
  author={Nesreen Nabil Omar and Reham Fathy Tash},
  journal={Pharmacology, biochemistry, and behavior},
  year={2017},
  volume={160},
  pages={
          30-38
        }
}
BACKGROUND Recently, depression has been envisioned as more than an alteration in neurotransmitters centered around receptor signaling pathways. Consequently, the precise mechanisms of selective serotonin reuptake inhibitor (SSRI) antidepressant drugs such as fluoxetine are being revisited. Zinc is a trace element that has been long implicated in the psychopathology and therapy of depression. Zinc has been found to be sequestered and dispensed during stress and inflammation through a family of… CONTINUE READING