Fluoxetine compared with amitriptyline in elderly depression: a controlled clinical trial.

Abstract

Twenty-eight elderly inpatients suffering from major depressive episodes (diagnosed according to DSM III) received randomly, on a double-blind basis, amitriptyline (75 mg/die) or fluoxetine (20 mg/die) for five weeks. There were four drop-outs in the amitriptyline group and two drop-outs in the fluoxetine group. Both groups showed a significant amelioration at the end point for Hamilton Rating Scale of Depression scores compared to the baseline value. Anticholinergic side-effects were significantly more severe in the amitriptyline group. Weight gain was detected only in patients receiving amitriptyline.

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@article{Altamura1989FluoxetineCW, title={Fluoxetine compared with amitriptyline in elderly depression: a controlled clinical trial.}, author={Alfredo Carlo Altamura and Francesca de Novellis and G Guercetti and Giordano Invernizzi and Mauro Percudani and Stuart A. Montgomery}, journal={International journal of clinical pharmacology research}, year={1989}, volume={9 6}, pages={391-6} }