Fluoxetine attenuates the inhibitory effect of glucocorticoid hormones on neurogenesis in vitro via a two-pore domain potassium channel, TREK-1

@article{Xi2010FluoxetineAT,
  title={Fluoxetine attenuates the inhibitory effect of glucocorticoid hormones on neurogenesis in vitro via a two-pore domain potassium channel, TREK-1},
  author={Guangjun Xi and Xiangrong Zhang and Ling Zhang and Yuxiu Sui and Jiaojie Hui and Shanshan Liu and Yingxin Wang and Lingjiang Li and Zhi-Jun Zhang},
  journal={Psychopharmacology},
  year={2010},
  volume={214},
  pages={747-759}
}
Sustained stress and elevated glucocorticoid reduces neurogenesis, whereas chronic treatment with antidepressants increases neurogenesis and blocks the effects of stress. Recently, TREK-1, a two-pore domain (K2p) potassium channel, has been shown to be involved in the mechanisms of major depression. This study aimed to investigate whether TREK-1 is involved in the alteration of neurogenesis according to glucocorticoids and antidepressants. The present study addressed the expression of TREK-1 in… CONTINUE READING
Highly Cited
This paper has 97 citations. REVIEW CITATIONS
18 Citations
60 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 18 extracted citations

97 Citations

0204060'12'14'16'18
Citations per Year
Semantic Scholar estimates that this publication has 97 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
Showing 1-10 of 60 references

Similar Papers

Loading similar papers…