Fluoxetine and norfluoxetine stereospecifically and selectively increase brain neurosteroid content at doses that are inactive on 5-HT reuptake

@article{Pinna2005FluoxetineAN,
  title={Fluoxetine and norfluoxetine stereospecifically and selectively increase brain neurosteroid content at doses that are inactive on 5-HT reuptake},
  author={G. Pinna and E. Costa and A. Guidotti},
  journal={Psychopharmacology},
  year={2005},
  volume={186},
  pages={362-372}
}
  • G. Pinna, E. Costa, A. Guidotti
  • Published 2005
  • Medicine
  • Psychopharmacology
  • It has recently become more clearly understood that in human brain pathophysiology, neurosteroids play a role in anxiety disorders, premenstrual syndrome, postpartum depression, posttraumatic stress disorder, and depression. In the treatment of major depression, recent clinical studies indicate that the pharmacological profiles of fluoxetine and fluvoxamine are correlated with the ability of these drugs to increase the brain and cerebrospinal fluid content of allopregnanolone (Allo), a potent… CONTINUE READING
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    References

    SHOWING 1-10 OF 112 REFERENCES
    The anticonvulsant action of fluoxetine in substantia nigra is dependent upon endogenous serotonin
    • 60
    Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine.
    • 575
    • PDF
    Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes.
    • L. D. Griffin, S. Mellon
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 1999
    • 342
    • PDF
    Tianeptine, a selective enhancer of serotonin uptake in rat brain
    • 107
    Fluoxetine and norfluoxetine stereospecifically facilitate pentobarbital sedation by increasing neurosteroids.
    • 60
    • PDF
    Selectivity of antidepressants: from the monoamine hypothesis of depression to the SSRI revolution and beyond.
    • M. Owens
    • Psychology, Medicine
    • The Journal of clinical psychiatry
    • 2004
    • 105
    • Highly Influential
    The serotonergic and noradrenergic systems of the hippocampus: their interactions and the effects of antidepressant treatments
    • 395
    • Highly Influential