Fluoxetine and citalopram decrease microglial release of glutamate and D-serine to promote cortical neuronal viability following ischemic insult.

@article{Dhami2013FluoxetineAC,
  title={Fluoxetine and citalopram decrease microglial release of glutamate and D-serine to promote cortical neuronal viability following ischemic insult.},
  author={Kamaldeep S Dhami and Matthew A. Churchward and Glen B Baker and Kathryn G. Todd},
  journal={Molecular and cellular neurosciences},
  year={2013},
  volume={56},
  pages={365-74}
}
Depression is one of the most common disorders appearing following a stroke, and is also a major factor limiting recovery and rehabilitation in stroke patients. Antidepressants are the most common prescribed treatment for depression and have shown to have anti-inflammatory properties within the central nervous system (CNS). The major source of pro-inflammatory factors within the CNS is from activated microglia, the innate immune cells of the CNS. Antidepressants have been shown to promote… CONTINUE READING