Fluoxetine Partly Exerts its Actions Through GABA: A Neurochemical Evidence

  title={Fluoxetine Partly Exerts its Actions Through GABA: A Neurochemical Evidence},
  author={Mehmet Zafer G{\"o}ren and Esra K{\"u}ç{\"u}kibrahimoğlu and Kemal Berkman and Berna Terzioğlu},
  journal={Neurochemical Research},
Fluoxetine, as a serotonin re-uptake inhibitor augments serotonin concentration within the synapse by inhibiting the serotonin transporter. The contribution of amino acids has also been shown in depression. We hypothesized that fluoxetine exerts its actions at least in part by intervening brain signaling operated by amino acid transmitters. Therefore the aim of this study is to supply neurochemical evidence that fluoxetine produces changes in amino acids in cerebrospinal fluid of rats. Sprague… CONTINUE READING


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