Fluoxetine Induced Fecal Incontinence in a 9 Year Old Child with Autistic Spectrum Disorder: A Case Report

Abstract

Despite the dramatic rise in the use of selective serotonin reuptake inhibitors (SSRIs) in children and adolescents, there are still concerns about the tolerability of these agents in younger ages (1). It is suggested that, in general, children and adolescents may be more vulnerable to some adverse effects of these agents when compared with adults (2,3). The adverse effects of SSRIs may be classified in several subgroups including gastrointestinal adverse effects (GIS-AE), sleep disturbances, physical symptoms, and psychiatric adverse effects (PAE) (1,4). The etiopathology and course of these reactions is not completely identified. Pervasive developmental disorders (PDD) are characterized by impairments in reciprocal social interaction and communication plus restrictive, repetitive and stereotypic behaviors, activities and interests (5). In the milder forms of PDD, especially in PDD-NOS, Asperger’s Syndrome and high functioning autism (HFA), patients may exhibit depressive and/or anxiety disorder symptoms which are sometimes reactive to difficulties of socialization and academic failure (6-9). It’s suggested that children and adolescents with developmental disabilities and PDD may be more prone to the adverse effects of SSRIs (10). To date, one placebo controlled and three open label studies have been conducted to examine the use and tolerability of fluoxetine in children with PDD. All four studies yielded encouraging results for its efficacy and more variable results for its tolerability (11-14). The only placebo controlled study, conducted by Hollander et al. (14), interestingly showed that fluoxetine was almost as tolerable as placebo. However, by contrast, three open labels studies offered more equivocal rates of tolerability (11-13). GIS-AE including nausea, vomiting, diarrhea and upset stomachs are commonly reported when using SSRIs Fluoxetine Induced Fecal Incontinence in a 9 Year Old Child with Autistic Spectrum Disorder: A Case Report

Cite this paper

@inproceedings{Ekinci2009FluoxetineIF, title={Fluoxetine Induced Fecal Incontinence in a 9 Year Old Child with Autistic Spectrum Disorder: A Case Report}, author={Ozalp Ekinci and Osman Sabuncuo¤lu and Meral Berkem}, year={2009} }