Fluoxetine Dose-Increment Related Akathisia in Depression: Implications for Clinical Care, Recognition and Management of Selective Serotonin Reuptake Inhibitor-Induced Akathisia

@article{Hansen2003FluoxetineDR,
  title={Fluoxetine Dose-Increment Related Akathisia in Depression: Implications for Clinical Care, Recognition and Management of Selective Serotonin Reuptake Inhibitor-Induced Akathisia},
  author={L. Hansen},
  journal={Journal of Psychopharmacology},
  year={2003},
  volume={17},
  pages={451 - 452}
}
  • L. Hansen
  • Published 2003
  • Psychology, Medicine
  • Journal of Psychopharmacology
We report the case of a 22-year-old woman presenting major depressive episode with severe akathisia after an increase in fluoxetine. The patient developed severe restlessness andde novosuicidal ideation approximately 1 week after the dosage of fluoxetine was doubled, 1 year on from when the drug was first introduced. This case illustrates the importance of being alert to movement disorders in patients treated with selective serotonin reuptake inhibitors. The clinical implications are discussed… Expand
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15 Citations
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15 Citations

Citation Type

Citation Type

Selective serotonin reuptake inhibitor-induced akathisia.
TLDR
Pharmacists can play an active role in recognizing akathisia by being aware of its characteristics, conducting a thorough medication history to identify causative agents, and using BARS to evaluate patients. Expand
Akathisia Induced by Mirtazapine After 20 Years of Continuous Treatment
TLDR
The reappearance of the symptoms after the patient had been rechallenged with mirtazapine ascertained the diagnosis of akathisia induced by mirtzapine, and illustrates the importance of being alert to any movement disorder emerging in patients treated with mIRTazAPine, even after many years of treatment. Expand
[Akathisia--diagnosis, pathophysiology and therapy].
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The paper describes the historical context of disorder defined as akathisia, its clinical course, pathophysiology, as well as therapy. Expand
Extrapyramidal Reactions Associated With Serotonergic Antidepressants
TLDR
A follow-up review of published EPR cases reported for serotonergic antidepressants, finding that age, gender, antidepressant dosing, or concurrent antipsychotic treatment did not appear to broadly contribute to EPR risk. Expand
Antidepressant-induced jitteriness/anxiety syndrome: systematic review
TLDR
Jitteriness/anxiety syndrome remains poorly characterised and clinicians' perception of this syndrome influences prescribing and it is cited to support postulated mechanisms of drug action, but systematised evaluation of side-effects at earlier time points in antidepressant trials to further elucidate this clinically important syndrome. Expand
Evaluation of akathisia in patients with schizophrenia, schizoaffective disorder, or bipolar I disorder: a post hoc analysis of pooled data from short- and long-term aripiprazole trials
TLDR
Akathisia with aripiprazole occurred early in treatment, was mild-to-moderate in severity, led to few study discontinuations, and did not compromise therapeutic efficacy. Expand
Tardive dyskinesia: Epidemiology
TLDR
While the change from the "first generation" to the "second generation" of antipsychotic drugs is generally believed to have reduced the incidence of TS, prospective research studies have not supported that contention and it is clear that TS remains a significant and common problem associated with almost all antipsychotics. Expand
post hoc analysis of pooled data from short-and long-term aripiprazole trials Evaluation of akathisia in patients with schizophrenia , schizoaffective disorder , or bipolar I disorder : a
The objective of this article is to assess the clinical characteristics of akathisia in patients with schizophrenia, schizoaffective disorder, or bipolar I disorder receiving aripiprazole,… Expand
Dextromethorphan abuse: clinical effects and management.
TLDR
Clinicians should be aware of the abuse potential of dextromethorphan and be particularly cognizant of the risks involved with DM abuse as they control OTC access to the drug. Expand
Antidepressant dose, age, and the risk of deliberate self-harm.
TLDR
Clinicians are offered an additional incentive to avoid initiating pharmacotherapy at high-therapeutic doses and to closely monitor patients starting antidepressants, especially youth, for several months to assess the risk of deliberate self-harm. Expand
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