Fluoxetine: a case history of its discovery and preclinical development

@article{PrezCaballero2014FluoxetineAC,
  title={Fluoxetine: a case history of its discovery and preclinical development},
  author={L. P{\'e}rez-Caballero and S. Torres-Sanchez and L. Bravo and J. Mic{\'o} and E. Berrocoso},
  journal={Expert Opinion on Drug Discovery},
  year={2014},
  volume={9},
  pages={567 - 578}
}
Introduction: Depression is a multifactorial mood disorder with a high prevalence worldwide. Until now, treatments for depression have focused on the inhibition of monoaminergic reuptake sites, which augment the bioavailability of monoamines in the CNS. Advances in drug discovery have widened the therapeutic options with the synthesis of so-called selective serotonin reuptake inhibitors (SSRIs), such as fluoxetine. Areas covered: The aim of this case history is to describe and discuss the… Expand
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