Fluoxetine, but not Tricyclic Antidepressants, Potentiates the 5-Hydroxytryptophan-Mediated Increase in Plasma Cortisol and Prolactin Secretion in Subjects with Major Depression or with Obsessive Compulsive Disorder

@article{Meltzer1997FluoxetineBN,
  title={Fluoxetine, but not Tricyclic Antidepressants, Potentiates the 5-Hydroxytryptophan-Mediated Increase in Plasma Cortisol and Prolactin Secretion in Subjects with Major Depression or with Obsessive Compulsive Disorder},
  author={Herbert A Meltzer and Bijan Bastani and Karuna Jayathilake and Michael Maes},
  journal={Neuropsychopharmacology},
  year={1997},
  volume={17},
  pages={1-11}
}
It has been suggested that the clinical efficacy of chronic treatment with selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine and perhaps all antidepressants is due to their ability to enhance serotonergic activity. The effects of chronic treatment with fluoxetine or tricyclic antidepressants on the L-5-hydroxytryptophan (200 mg, L-5-HTP; PO)–induced increases in plasma cortisol and prolactin (PRL) concentrations were studied in patients with major depression or obsessive… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 3 times over the past 90 days. VIEW TWEETS
24 Citations
70 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 24 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 70 references

The serotonin hypothesis of major depression. In: Bloom FE, Kupfer DJ (eds), Psychopharmacology, the Fourth Generation of Progress

  • M Maes, Meltzer
  • HYM
  • 1995
Highly Influential
4 Excerpts

Effect of 5-hydroxytryptophan on serum cortisol levels in major affective disorders: Enhanced response in depression and mania

  • HY Meltzer, B Wiita, A Robertson, BJ Tricou, M Lowy, R Perline
  • Arch Gen Psychiatr
  • 1984
Highly Influential
8 Excerpts

Effects of pindolol and 5-HTPinduced prolactin and cortisol responses

  • HY Meltzer, M Maes
  • Psychopharmacol
  • 1994
Highly Influential
7 Excerpts

The involvement of serotonin in regulation of pituitary-adrenocortical function

  • RW Fuller
  • Front Neuroendocrinol
  • 1992
Highly Influential
4 Excerpts

Pre- and postsynaptic modifications of the serotonin system by longterm administration of antidepressant treatments: An in vivo electrophysiological study in the rat

  • Y Chaput, C De Montigney, P Blier
  • Neuropsychopharmacology
  • 1991
Highly Influential
7 Excerpts

A role for the serotonin system in the mechanism of action of antidepressant treatments: Preclinical evidence

  • P Blier, G de Montigny, Y Chaput
  • J Clin Psychiatr
  • 1990
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…