Fluoxetine, Desipramine, and the Dual Antidepressant Milnacipran Reduce Alcohol Self-Administration and/or Relapse in Dependent Rats

@article{OBrien2011FluoxetineDA,
  title={Fluoxetine, Desipramine, and the Dual Antidepressant Milnacipran Reduce Alcohol Self-Administration and/or Relapse in Dependent Rats},
  author={Emmanuelle Simon O'Brien and R{\'e}mi Legastelois and Hakim Houchi and Catherine Vilpoux and St{\'e}phanie Alaux-Cantin and Olivier Pierrefiche and Etienne Andr{\'e} and Micka{\"e}l Naassila},
  journal={Neuropsychopharmacology},
  year={2011},
  volume={36},
  pages={1518-1530}
}
A few clinical studies have shown that dual antidepressants (serotonergic (5-HT) and noradrenergic (NE) transporter inhibitors, SNRIs) may be effective in alcoholism treatment. We studied the effect of the dual antidepressant milnacipran on ethanol operant self-administration in acutely withdrawn ethanol-dependent and in -non-dependent Wistar rats, and used fluoxetine and desipramine to dissect both 5-HT and NE components, respectively, in the effect of milnacipran. Milnacipran was also tested… CONTINUE READING

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