Fluorous synthesis of substituted sclerotigenin library.

  title={Fluorous synthesis of substituted sclerotigenin library.},
  author={Y. Lu and T. Nagashima and B. Miriyala and J. Conde and Wei Zhang},
  journal={Journal of combinatorial chemistry},
  volume={12 1},
  • Y. Lu, T. Nagashima, +2 authors Wei Zhang
  • Published 2010
  • Chemistry, Medicine
  • Journal of combinatorial chemistry
A fluorous linker-assisted synthetic protocol has been developed for preparation of sclerotigenin-type benzodiazepine-quinazolinone library containing 144 analogues. Amide coupling of fluorous trimethoxybenzyl (TMB)-protected amino esters with anthranilic acids followed by base-promoted cyclizations afforded 4-benzodiazepine-2,5-diones. Further derivatization of benzodiazepinediones by reacting with azidobenzoyl chlorides, cyclization, and fluorous linker cleavage afforded the desired compound… Expand
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