Fluorous methods for the synthesis of peptides and oligonucleotides.

@article{Miriyala2012FluorousMF,
  title={Fluorous methods for the synthesis of peptides and oligonucleotides.},
  author={B. Miriyala},
  journal={Topics in current chemistry},
  year={2012},
  volume={308},
  pages={
          105-33
        }
}
  • B. Miriyala
  • Published 2012
  • Chemistry, Medicine
  • Topics in current chemistry
The non-covalent affinity of a perfluoro chain towards similar has been exploited by many to separate fluorous tagged compounds from non-fluorous compounds by F-SPE or F-LLE. This purification strategy found its application across diverse fields including peptide and oligonucleotide synthesis where even slight inefficient couplings result in deletion sequences that are often difficult to remove from the target sequence. Two commonly employed strategies to address this problem involve end… Expand
Fluorous affinity-based separation techniques for the analysis of biogenic and related molecules.
Liquid-phase combinatorial library synthesis: recent advances and future perspectives.

References

SHOWING 1-10 OF 32 REFERENCES
Fluorous affinity purification of oligonucleotides.
Froc: a new fluorous protective group for peptide and oligosaccharide synthesis.
Fluorous (trimethylsilyl)ethanol: a new reagent for carboxylic acid tagging and protection in peptide synthesis.
Just add water: a new fluorous capping reagent for facile purification of peptides synthesized on the solid phase.
Peptide synthesis on fluorous support
A novel peptide synthesis using fluorous chemistry.
A Fluorous Capping Strategy for Fmoc‐Based Automated and Manual Solid‐Phase Peptide Synthesis
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