Fluorouracil versus combination of irinotecan plus cisplatin versus S-1 in metastatic gastric cancer: a randomised phase 3 study

@article{Boku2009FluorouracilVC,
  title={Fluorouracil versus combination of irinotecan plus cisplatin versus S-1 in metastatic gastric cancer: a randomised phase 3 study},
  author={Narikazu Boku and Seiichiro Yamamoto and Haruhiko Fukuda and Kuniaki Shirao and Toshihiko Doi and Akira Sawaki and Wasaburo Koizumi and Hiroshi Saito and Kensei Yamaguchi and Hiroya Takiuchi and Junichiro Nasu and Atsushi Ohtsu},
  journal={The Lancet. Oncology},
  year={2009},
  volume={10 11},
  pages={
          1063-9
        }
}
BACKGROUND The best chemotherapy regimen for metastatic gastric cancer is uncertain, but promising findings have been reported with irinotecan plus cisplatin and S-1 (tegafur, 5-chloro-2,4-dihydropyrimidine, and potassium oxonate). We aimed to investigate the superiority of irinotecan plus cisplatin and non-inferiority of S-1 compared with fluorouracil, with respect to overall survival, in patients with metastatic gastric cancer. METHODS We undertook a phase 3 open label randomised trial in… CONTINUE READING
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