Fluoroquinolones in Children With Fever and Neutropenia: A Systematic Review of Prospective Trials

@article{Sung2012FluoroquinolonesIC,
  title={Fluoroquinolones in Children With Fever and Neutropenia: A Systematic Review of Prospective Trials},
  author={Lillian Sung and Arif Manji and Joseph Beyene and Lee L. Dupuis and Sarah Alexander and Robert Phillips and Thomas Lehrnbecher},
  journal={The Pediatric Infectious Disease Journal},
  year={2012},
  volume={31},
  pages={431–435}
}
Background: There has been reluctance to use fluoroquinolones in children because of arthropathy in animal models; experience in pediatric fever and neutropenia (FN) has been limited. Our primary objective was to describe the effectiveness and safety of fluoroquinolones as empiric therapy for children with FN. Methods: We conducted electronic searches of Ovid Medline, EMBASE, the Cochrane Central Register of Controlled Trials, and limited studies to prospective pediatric trials in which any… 

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