Fluoroquinolones: mechanism of action, classification, and development of resistance.

@article{Blondeau2004FluoroquinolonesMO,
  title={Fluoroquinolones: mechanism of action, classification, and development of resistance.},
  author={Joseph M. Blondeau},
  journal={Survey of ophthalmology},
  year={2004},
  volume={49 Suppl 2},
  pages={S73-8}
}
The fluoroquinolones represent an evolving class of broad-spectrum antimicrobial agents used in the prevention and treatment of a variety of ocular infections; however, resistance to currently available agents in the class has been emerging among ocular pathogens. This article reviews the mechanism of action of existing and new fluoroquinolones and discusses the structure-activity relationship of the fluoroquinolones as it relates to the classification of these compounds. This article also… CONTINUE READING