Fluoroquinolone-resistant Neisseria gonorrhoeae isolates from Russia: molecular mechanisms implicated.

@article{Vereshchagin2004FluoroquinoloneresistantNG,
  title={Fluoroquinolone-resistant Neisseria gonorrhoeae isolates from Russia: molecular mechanisms implicated.},
  author={V. A. Vereshchagin and Elena N. Ilina and M. V. Malakhova and M. M. Zubkov and S. V. Sidorenko and Anna A. Kubanova and Vadim M. Govorun},
  journal={The Journal of antimicrobial chemotherapy},
  year={2004},
  volume={53 4},
  pages={
          653-6
        }
}
OBJECTIVES During a longitudinal study of the prevalence of antimicrobial resistance in Neisseria gonorrhoeae, a number of high-level fluoroquinolone-resistant isolates were obtained from the sexually transmitted diseases clinic in the Moscow region in 2002. The aim of the present study was to determine the molecular mechanisms of resistance and to assess the clonal relationship of these strains METHODS For the 32 clinical strains of N. gonorrhoeae studied, the MIC values were determined for… 
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CHROMOSOMAL ANTIBIOTIC RESISTANCE MECHANISMS IN PSEUDOMONAS AERUGINOSA AND NEISSERIA GONORRHOEAE
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Genomic surveillance of Neisseria gonorrhoeae to investigate the distribution and evolution of antimicrobial-resistance determinants and lineages
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A detailed picture of the distribution of resistance determinants and the evolution of the two major lineages spreading worldwide is provided and a sequence type (ST)7363 sub-lineage susceptible to ceftriaxone and cefixime is discovered in which the mosaic penA allele responsible for reduced susceptibility had reverted to a susceptible allele by recombination.
Molecular basis of high-level ciprofloxacin resistance in Neisseria gonorrhoeae strains from Shandong Province, China
  • L. Zhao, S.P. Zhao
  • Biology, Medicine
    Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]
  • 2013
TLDR
It is confim that gyrA mutations are necessary for the fluoroquinolone resistance phenotype and parC mutations are correlated intimately with high-level ciprofloxacin resistance.
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