Fluoroquinolone resistance of Serratia marcescens: involvement of a proton gradient-dependent efflux pump.

@article{Kumar2002FluoroquinoloneRO,
  title={Fluoroquinolone resistance of Serratia marcescens: involvement of a proton gradient-dependent efflux pump.},
  author={Ayush Kumar and Elizabeth A. Worobec},
  journal={The Journal of antimicrobial chemotherapy},
  year={2002},
  volume={50 4},
  pages={593-6}
}
OBJECTIVE To determine the presence of a proton gradient-dependent efflux of fluoroquinolone drugs in Serratia marcescens. METHODS Thirteen clinical isolates of S. marcescens were screened for resistance to four fluoroquinolones: ofloxacin, ciprofloxacin, norfloxacin and nalidixic acid by determining MICs. The presence of a proton gradient-dependent efflux mechanism was assessed using ethidium bromide accumulation assays. Drug accumulation studies for norfloxacin, ciprofloxacin and ofloxacin… CONTINUE READING