Fluoroquinolone-induced tendinopathy: what do we know?

  title={Fluoroquinolone-induced tendinopathy: what do we know?},
  author={R M Harrell},
  journal={Southern medical journal},
  volume={92 6},
  • R. Harrell
  • Published 1 June 1999
  • Medicine
  • Southern medical journal
Fluoroquinolones are relatively safe, effective antibiotics. As their use becomes more frequent, so will the adverse side effects. I highlight a rare but debilitating adverse reaction-fluoroquinolone-induced tendinopathy. Case reports and letters from 1987 to 1998 were identified by using Grateful Med and PubMed Internet accesses to the National Library of Medicine. Articles were reviewed for clinical practicality. There are few articles on fluoroquinolone-induced tendinopathy in the US… 

Fluoroquinolone‐Associated Tendinopathy: Does Levofloxacin Pose the Greatest Risk?

A comprehensive summary of the risk of tendinopathy associated with levofloxacin, one of the most widely prescribed antibiotics in the United States, across in vitro, animal, and clinical studies, relative to other antibiotics is provided.

Fluoroquinolone-associated tendinopathy.

Because of the frequent use of FQs in clinical practice, physicians should be aware of their potential for severe disability from tendon rupture, with reports markedly increasing, especially with the use of ciprofloxacin.

Levofloxacin-Induced Bilateral Achilles Tendinopathy

A similar case from North America is reported and the literature on fluoroquinolone-induced tendinopathy is reviewed, which is a debilitating but rare complication that is of particular concern.

Fluoroquinolone-associated tendinopathy: a critical review of the literature.

  • Y. KhaliqG. Zhanel
  • Medicine, Biology
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2003
Tendon injury associated with fluoroquinolone use is significant, and risk factors such as renal disease or concurrent corticosteroid use must be considered when these agents are prescribed.

Quinolones: a comprehensive review.

The new fluoroquinolones are rarely first-line agents and should be employed judiciously, and inappropriate use of agents from this important class of antibiotics will likely worsen current problems with antibiotic resistance.

Bilateral Levofloxacin-Induced Achilles Tendon Rupture: An Uncommon Case Report and Review of the Literature

The purpose of this case report is to present the challenging diagnosis of a bilateral rupture of Achilles tendon in an old patient, because of the uncommon of the presentation and to review the current literature on such a debilitating condition.

Quinolone-associated tendonitis: a potential problem in COPD?

The finding of two cases of levofloxacin-induced tendinopathy in patients with severe chronic obstructive pulmonary disease suggests that the problem may be more frequent than previously considered.

Safety profile of quinolone antibiotics in the pediatric population.

  • R. Grady
  • Medicine, Biology
    The Pediatric infectious disease journal
  • 2003
A review of retrospective and prospective safety data of ciprofloxacin-treated children showed that the rates of arthralgia and quinolone-induced cartilage toxicity were low and the role of fluoroquinolones in the treatment of certain serious infections in children does not appear to be compromised by safety concerns when used appropriately.

Fluoroquinolones and BK Virus Nephropathy: A Myth or a Reality

This review will focus the evidence available for using fluoroquinolones in prevention of BKVN and its usefulness, and a way forward to use these agents or not for Prevention of BkVN will also be discussed.



Fluoroquinolone induced tendinopathy: report of 6 cases.

Although proper dosage and duration of treatment were respected, the principal fluoroquinolones were clearly incriminated and immediate discontinuation of the antibiotic and placement of both Achilles tendons at rest is essential.

Epicondylitis after treatment with fluoroquinolone antibiotics.

The two cases of epicondylitis of the elbow occurring after treatment with fluoroquinolone antibiotics indicate the need for caution when prescribing these antibiotics to patients at risk of tendon lesions, such as top-level sportsmen or patients on dialysis or steroid treatment.

Tendinitis Associated with Ciprofloxacin

I. Davis H, McGoodwin E, Reed TG. Anaphylactoid reactions reported after treatment with ciprofloxacin. Ann Intern Med 1989;111: 1041-3. 2. Deamer RL, Prichard JG, Loman GJ. Hypersensitivity and

Magnetic resonance imaging may be an asset to diagnose and classify fluoroquinolone‐associated Achilles tendinitis

It was concluded that MRI appears a helpful and accurate method in identifying and classifying such iatrogenic tendinitis and indicates orthopedic management when detecting risk of rupture.

Fluoroquinolone antimicrobial agents.

The fluoroquinolones offer an efficacious, well-tolerated, and cost-effective alternative to parenteral therapies of selected infections and show promise for therapy of prostatitis, respiratory tract infections, osteomyelitis, and cutaneous infections.

Fluoroquinolone antimicrobial agents

The fluoroquinolones offer an efficacious, well-tolerated, and cost-effective alternative to parenteral therapies of selected infections and show promise for therapy of prostatitis, respiratory tract infections, osteomyelitis, and cutaneous infections.

Tendinopathies et fluoro-quinolones

Les fluoro-quinolones prennent une importance croissante en therapeutique anti-infectieuse de par leur large spectre antibacterien, leurs qualites pharmacocinetiques et leur bonne tolerance.

Tendinopathies et fluoroquinolones

La mise en route d'un traitement par fluoroquinolones doit inciter a la prudence et a prevenir les patients d'interrompre le traitement au moindre signe precurseur de tendinite.

Seven Achilles tendinitis including 3 complicated by rupture during fluoroquinolone therapy.

7 Achilles tendinitis occurring during fluoroquinolone treatment was described, in 3 cases the course was complicated by rupture of the tendon, one of which is histologically documented.

Pathology of the Achilles Tendon in Association with Ciprofloxacin Treatment

Microscopic evaluation of patients with ciprofloxacin-associated Achilles tendon disease showed irregular collagen fiber arrangement, hypercellularity, and increased interfibrillar glycosaminoglycans, also seen in tendon overuse injuries in athletes.