Fluoroquinolone-induced tendinopathy: what do we know?

@article{Harrell1999FluoroquinoloneinducedTW,
  title={Fluoroquinolone-induced tendinopathy: what do we know?},
  author={R M Harrell},
  journal={Southern medical journal},
  year={1999},
  volume={92 6},
  pages={
          622-5
        }
}
  • R. Harrell
  • Published 1 June 1999
  • Medicine
  • Southern medical journal
Fluoroquinolones are relatively safe, effective antibiotics. As their use becomes more frequent, so will the adverse side effects. I highlight a rare but debilitating adverse reaction-fluoroquinolone-induced tendinopathy. Case reports and letters from 1987 to 1998 were identified by using Grateful Med and PubMed Internet accesses to the National Library of Medicine. Articles were reviewed for clinical practicality. There are few articles on fluoroquinolone-induced tendinopathy in the US… 

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...

References

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Fluoroquinolone induced tendinopathy: report of 6 cases.

Although proper dosage and duration of treatment were respected, the principal fluoroquinolones were clearly incriminated and immediate discontinuation of the antibiotic and placement of both Achilles tendons at rest is essential.

Epicondylitis after treatment with fluoroquinolone antibiotics.

The two cases of epicondylitis of the elbow occurring after treatment with fluoroquinolone antibiotics indicate the need for caution when prescribing these antibiotics to patients at risk of tendon lesions, such as top-level sportsmen or patients on dialysis or steroid treatment.

Tendinitis Associated with Ciprofloxacin

I. Davis H, McGoodwin E, Reed TG. Anaphylactoid reactions reported after treatment with ciprofloxacin. Ann Intern Med 1989;111: 1041-3. 2. Deamer RL, Prichard JG, Loman GJ. Hypersensitivity and

Magnetic resonance imaging may be an asset to diagnose and classify fluoroquinolone‐associated Achilles tendinitis

It was concluded that MRI appears a helpful and accurate method in identifying and classifying such iatrogenic tendinitis and indicates orthopedic management when detecting risk of rupture.

Fluoroquinolone antimicrobial agents.

The fluoroquinolones offer an efficacious, well-tolerated, and cost-effective alternative to parenteral therapies of selected infections and show promise for therapy of prostatitis, respiratory tract infections, osteomyelitis, and cutaneous infections.

Fluoroquinolone antimicrobial agents

The fluoroquinolones offer an efficacious, well-tolerated, and cost-effective alternative to parenteral therapies of selected infections and show promise for therapy of prostatitis, respiratory tract infections, osteomyelitis, and cutaneous infections.

Tendinopathies et fluoro-quinolones

Les fluoro-quinolones prennent une importance croissante en therapeutique anti-infectieuse de par leur large spectre antibacterien, leurs qualites pharmacocinetiques et leur bonne tolerance.

Tendinopathies et fluoroquinolones

La mise en route d'un traitement par fluoroquinolones doit inciter a la prudence et a prevenir les patients d'interrompre le traitement au moindre signe precurseur de tendinite.

Seven Achilles tendinitis including 3 complicated by rupture during fluoroquinolone therapy.

7 Achilles tendinitis occurring during fluoroquinolone treatment was described, in 3 cases the course was complicated by rupture of the tendon, one of which is histologically documented.

Pathology of the Achilles Tendon in Association with Ciprofloxacin Treatment

Microscopic evaluation of patients with ciprofloxacin-associated Achilles tendon disease showed irregular collagen fiber arrangement, hypercellularity, and increased interfibrillar glycosaminoglycans, also seen in tendon overuse injuries in athletes.