Fluoroquinolone efflux mediated by ABC transporters.

@article{lvarez2008FluoroquinoloneEM,
  title={Fluoroquinolone efflux mediated by ABC transporters.},
  author={Ana Isabel {\'A}lvarez and Miriam J. Perez and Julio Gabriel Prieto and Antonio Jos{\'e} Molina and Rebeca Real and Gracia Merino},
  journal={Journal of pharmaceutical sciences},
  year={2008},
  volume={97 9},
  pages={3483-93}
}
Quinolones and fluoroquinolones are broad spectrum bactericidal drugs, which are widely used in both human and veterinary medicine. These drugs can quite easily enter cells and are often used to treat intracellular pathogens. Some fluoroquinolones have been reported to undergo efflux, which could explain their low bioavailability. There is a growing need to understand resistance mechanisms to quinolones, involving for instance mutations or the action of efflux pumps. Several members of the ATP… CONTINUE READING