Fluoroquinolone antibiotics inhibit cytochrome P450-mediated microsomal drug metabolism in rat and human.

@article{McLellan1996FluoroquinoloneAI,
  title={Fluoroquinolone antibiotics inhibit cytochrome P450-mediated microsomal drug metabolism in rat and human.},
  author={RexB. McLellan and Robert K. Drobitch and Mario Monshouwer and Kenneth W. Renton},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1996},
  volume={24 10},
  pages={
          1134-8
        }
}
The fluoroquinolone antibacterial agents have gained widespread use in the treatment of a broad range of bacterial infections. We recently described a possible interaction concerning the concomitant use of cyclosporine A and norfloxacin in pediatric renal transplant patients. We examined the effect of two common fluoroquinolone antibiotics on cytochrome P450-mediated drug biotransformations in human and rat liver microsomes. Rats were pretreated with inducers, which increased the levels of the… CONTINUE READING

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