Fluoroquinolone Adverse Effects and Drug Interactions

@article{Fish2001FluoroquinoloneAE,
  title={Fluoroquinolone Adverse Effects and Drug Interactions},
  author={Douglas N. Fish},
  journal={Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy},
  year={2001},
  volume={21}
}
  • D. Fish
  • Published 1 October 2001
  • Biology, Medicine, Chemistry
  • Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
Extensive pharmacologic and clinical development of quinolone antimicrobial agents has resulted in improved antimicrobial activity, pharmacokinetic features, toxicity, and drug‐drug interaction profiles. Nalidixic acid and other early quinolones had limited use due to poor pharmacokinetics, relatively narrow antimicrobial spectrum of activity, and frequent adverse effects. Beginning with the development of fluoroquinolones, such as norfloxacin and ciprofloxacin, in the 1980s, the agents assumed… 

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...

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